藥用級膠態二氧化硅 1kg起定制發貨

本品系將四氯化硅在氫氣與氧氣火焰中反應而制得。按熾灼品計算，含SiO2應為99.0%～100.5%。　　【性狀】本品為白色疏松的粉末。　　本品在水中不溶，在熱的試液中溶解，在稀鹽酸中不溶。　　　　【類別】藥用輔料，助流劑、增稠劑、穩定劑等。　　【貯藏】密封保存。　　　　　　【標示】應標明松密度和比表面積的標示值。

藥用級膠態二氧化硅 1kg起定制發貨

常(chang)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)及最大(da)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)口服(fu)膠(jiao)囊劑(ji)(ji)(ji)最大(da)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)11.66mg;口服(fu)顆(ke)粒(li)劑(ji)(ji)(ji)最大(da)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)100.00mg;口服(fu)散(san)劑(ji)(ji)(ji)最大(da)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)4.5%;口服(fu)片劑(ji)(ji)(ji)最大(da)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)170.00;直腸栓劑(ji)(ji)(ji)最大(da)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)14.00mg;舌下片劑(ji)(ji)(ji)最大(da)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)1.00mg;[1]。已收載于(yu)(yu)(yu)FDA《非活性(xing)(xing)(xing)組(zu)分(fen)指南》（用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)(yu)口服(fu)膠(jiao)囊，混懸(xuan)劑(ji)(ji)(ji)和片劑(ji)(ji)(ji)；透(tou)皮(pi)和陰(yin)(yin)道(dao)給藥(yao)制劑(ji)(ji)(ji)）中(zhong)(zhong)。英國準許用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)(yu)非注射(she)(she)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)制劑(ji)(ji)(ji)。[1][1]R.C.羅(luo)(luo)，P.J.舍斯(si)基，P.J.韋勒(le)(le).藥(yao)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)輔(fu)料手(shou)(shou)冊(ce)[M].北(bei)(bei)京：化(hua)(hua)學(xue)工(gong)業(ye)(ye)出(chu)版(ban)社，2005.功能(neng)本(ben)品(pin)廣泛(fan)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)(yu)藥(yao)劑(ji)(ji)(ji)，化(hua)(hua)妝(zhuang)品(pin)和食(shi)品(pin)中(zhong)(zhong)。小粒(li)徑和大(da)比(bi)表面積使它具(ju)有期望的(de)(de)(de)(de)流動性(xing)(xing)(xing)，這一(yi)(yi)特點(dian)可(ke)(ke)在(zai)(zai)(zai)許多(duo)過(guo)程中(zhong)(zhong)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)來(lai)(lai)改善干(gan)粉的(de)(de)(de)(de)流動性(xing)(xing)(xing)，比(bi)如(ru)壓片過(guo)程。本(ben)品(pin)也可(ke)(ke)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)(yu)穩定(ding)乳劑(ji)(ji)(ji)，在(zai)(zai)(zai)凝膠(jiao)和半(ban)固(gu)體(ti)制劑(ji)(ji)(ji)中(zhong)(zhong)作為(wei)觸(chu)變性(xing)(xing)(xing)增黏劑(ji)(ji)(ji)（thixotropicthickeningagent）和助懸(xuan)劑(ji)(ji)(ji)。與其他具(ju)有相(xiang)似折射(she)(she)率的(de)(de)(de)(de)組(zu)分(fen)一(yi)(yi)起可(ke)(ke)以(yi)形成透(tou)明的(de)(de)(de)(de)凝膠(jiao)。其黏度(du)的(de)(de)(de)(de)增加取決于(yu)(yu)(yu)液體(ti)的(de)(de)(de)(de)極(ji)(ji)性(xing)(xing)(xing)（極(ji)(ji)性(xing)(xing)(xing)液體(ti)需要(yao)微分(fen)硅(gui)(gui)膠(jiao)的(de)(de)(de)(de)濃度(du)要(yao)高(gao)于(yu)(yu)(yu)非極(ji)(ji)性(xing)(xing)(xing)液體(ti)）。黏度(du)不(bu)受(shou)溫(wen)度(du)的(de)(de)(de)(de)影(ying)(ying)響(xiang)，但(dan)是體(ti)系pH的(de)(de)(de)(de)變化(hua)(hua)會影(ying)(ying)響(xiang)黏度(du)。在(zai)(zai)(zai)非吸(xi)入用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)氣霧劑(ji)(ji)(ji)中(zhong)(zhong)，本(ben)品(pin)常(chang)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)(yu)促進顆(ke)粒(li)的(de)(de)(de)(de)懸(xuan)浮性(xing)(xing)(xing)，以(yi)免產生堅(jian)硬Chemicalbook的(de)(de)(de)(de)沉淀，較少(shao)噴口堵塞。本(ben)品(pin)也可(ke)(ke)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)作片劑(ji)(ji)(ji)的(de)(de)(de)(de)崩解劑(ji)(ji)(ji)，在(zai)(zai)(zai)散(san)劑(ji)(ji)(ji)中(zhong)(zhong)作為(wei)液體(ti)的(de)(de)(de)(de)吸(xi)附分(fen)散(san)劑(ji)(ji)(ji)。本(ben)品(pin)也經(jing)常(chang)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)在(zai)(zai)(zai)含(han)親(qin)脂性(xing)(xing)(xing)基質(zhi)的(de)(de)(de)(de)栓劑(ji)(ji)(ji)中(zhong)(zhong)以(yi)增加黏性(xing)(xing)(xing)，以(yi)免成型過(guo)程中(zhong)(zhong)沉淀，降低釋(shi)放速率。安全膠(jiao)態(tai)二氧(yang)化(hua)(hua)硅(gui)(gui)廣泛(fan)應用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)(yu)口服(fu)和一(yi)(yi)些局部用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)制劑(ji)(ji)(ji)中(zhong)(zhong)，一(yi)(yi)般認為(wei)是無(wu)毒，無(wu)刺激(ji)的(de)(de)(de)(de)輔(fu)料。但(dan)腹腔和皮(pi)下注射(she)(she)可(ke)(ke)能(neng)導致(zhi)局部組(zu)織壞死和肉芽腫，因(yin)此二氧(yang)化(hua)(hua)硅(gui)(gui)不(bu)宜(yi)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)(yu)注射(she)(she)。LD50（大(da)鼠(shu)，IV）：15mg/kgLD50（大(da)鼠(shu)，口服(fu)）：3.16g/kg[1][1]R.C.羅(luo)(luo)，P.J.舍斯(si)基，P.J.韋勒(le)(le).藥(yao)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)輔(fu)料手(shou)(shou)冊(ce)[M].北(bei)(bei)京：化(hua)(hua)學(xue)工(gong)業(ye)(ye)出(chu)版(ban)社，2005.給藥(yao)途徑口服(fu)，吸(xi)入，經(jing)皮(pi)，舌下，陰(yin)(yin)道(dao)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)[分(fen)標識ETJ7Z6XBU4配伍禁忌與二乙基己烯(xi)雌酚有配伍禁忌[1][1]R.C.羅(luo)(luo)，P.J.舍斯(si)基，P.J.韋勒(le)(le).藥(yao)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)輔(fu)料手(shou)(shou)冊(ce)[M].北(bei)(bei)京：化(hua)(hua)學(xue)工(gong)業(ye)(ye)出(chu)版(ban)社，2005.來(lai)(lai)源膠(jiao)態(tai)二氧(yang)化(hua)(hua)硅(gui)(gui)是由氯代(dai)硅(gui)(gui)烷氣相(xiang)水(shui)解制得，例(li)如(ru)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)四氯化(hua)(hua)硅(gui)(gui)，在(zai)(zai)(zai)1800℃用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)氫氣、氧(yang)氣火焰燃燒制備。[1][1]R.C.羅(luo)(luo)，P.J.舍斯(si)基，P.J.韋勒(le)(le).藥(yao)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)輔(fu)料手(shou)(shou)冊(ce)[M].北(bei)(bei)京：化(hua)(hua)學(xue)工(gong)業(ye)(ye)出(chu)版(ban)社，2005.膠(jiao)態(tai)二氧(yang)化(hua)(hua)硅(gui)(gui)(藥(yao)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)輔(fu)料)