壹捌零玖壹捌柒(qi)肆(si)貮玖捌

 來(lai)源：四部   分(fen)類：藥用輔料   

 Erjiajiyafeng Dimethyl Sulfoxide

   C2H6OS 78.13   [67-68-5]

    本品(pin)可由(you)二甲硫醚在氧化(hua)氮存(cun)在下(xia)通(tong)過(guo)空氣氧化(hua)制得(de)；也可以(yi)從制造紙漿的副產(chan)物中制得(de)。

    本品按無水物計算，應不得少于99.5%。

    【性狀】本品為(wei)無色液體(ti)；無臭或幾乎無臭；有引濕性。

 ;   本品與(yu)水、或乙m能任意(yi)混溶(rong)，在烷烴中不溶(rong)。

    凝點(dian) 本品的(de)凝點(dian)（通則0613）為17.0～18.3℃。

 ;   折(zhe)光率 本品的折(zhe)光率（通則0622）為1.478～1.479。

    相對密度 本品的相對密度（通則0601）為(wei)1.095～1.105。

    【鑒別】（1）取(qu)本品(pin)5ml，置(zhi)試管(guan)中(zhong)，加氯(lv)化鎳50mg，振搖使溶(rong)(rong)(rong)解，溶(rong)(rong)(rong)液(ye)(ye)呈(cheng)(cheng)黃綠(lv)(lv)色(se)，置(zhi)50℃水浴中(zhong)加熱，溶(rong)(rong)(rong)液(ye)(ye)呈(cheng)(cheng)綠(lv)(lv)色(se)或藍綠(lv)(lv)色(se)，放冷，溶(rong)(rong)(rong)液(ye)(ye)呈(cheng)(cheng)黃綠(lv)(lv)色(se)。

    （2）本品(pin)的紅外光吸收圖譜應與對照品(pin)的圖譜一致（通(tong)則0402）。

    【檢查】酸度 取本(ben)品50.0g，加水100ml溶解后，加酚酞(tai)指示液0.1ml，用滴(di)定(ding)液（0.01mol/L）滴(di)定(ding)至溶液顯粉紅色(se)，消耗滴(di)定(ding)液（0.01mol/L）不(bu)得過(guo)5.0ml。

    吸(xi)(xi)光(guang)度(du)(du) 取本(ben)品(pin)適量，通(tong)人干燥氮氣15分鐘，以水(shui)為空(kong)白，照紫外-可見分光(guang)光(guang)度(du)(du)法（通(tong)則0401），立即測定，在(zai)275nm波(bo)長(chang)處的吸(xi)(xi)光(guang)度(du)(du)不(bu)得大于0.30；在(zai)285nm與(yu)295mn波(bo)長(chang)處的吸(xi)(xi)光(guang)度(du)(du)與(yu)275nm波(bo)長(chang)處的吸(xi)(xi)光(guang)度(du)(du)的比(bi)值，分別不(bu)得過0.65與(yu)0.45；在(zai)270～350nm的波(bo)長(chang)范圍(wei)內，不(bu)得有大吸(xi)(xi)收峰。

    變深物 精密量取本品25ml，置(zhi)50ml量瓶中，加(jia)水(shui)0.5ml與1.0g，密塞，在(zai)水(shui)浴上加(jia)熱20分鐘，放冷，將溶液(ye)置(zhi)1cm吸(xi)收池中，以(yi)水(shui)為空(kong)白溶液(ye)，照紫外-可見分光光度法（通則(ze)0401），在(zai)350nm的(de)波長處測(ce)定(ding)吸(xi)光度，不得大于(yu)0.023。

    水(shui)(shui)分 取本品，照水(shui)(shui)分測定(ding)法（通則0832法1）測定(ding)，含(han)水(shui)(shui)分不(bu)得過0.2%。

    有(you)關物質(zhi) 取本(ben)品(pin)(pin)，精(jing)密稱定(ding)，用內(nei)標溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)（0.025%二(er)苯甲(jia)烷的丙酮(tong)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)）稀釋(shi)制成(cheng)(cheng)50%的溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)，作為(wei)供試(shi)(shi)(shi)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)；取供試(shi)(shi)(shi)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)適量，加(jia)內(nei)標溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)稀釋(shi)成(cheng)(cheng)0.050%的溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)，作為(wei)對照(zhao)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)；取二(er)甲(jia)基(ji)(ji)砜(feng)對照(zhao)品(pin)(pin)適量，精(jing)密稱定(ding)，用上述內(nei)標溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)稀釋(shi)制成(cheng)(cheng)0.050%的溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)，作為(wei)二(er)甲(jia)基(ji)(ji)砜(feng)對照(zhao)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)；照(zhao)氣相(xiang)色(se)(se)譜法（通則0521）試(shi)(shi)(shi)驗，以10%聚乙二(er)醇20M為(wei)固定(ding)液(ye)(ye)(ye)(ye)(ye)，柱溫為(wei)150℃，FID檢測(ce)器(qi)；理(li)論板數按二(er)甲(jia)基(ji)(ji)砜(feng)峰(feng)計(ji)算(suan)不低于(yu)1500，二(er)甲(jia)基(ji)(ji)砜(feng)峰(feng)與內(nei)標峰(feng)的分離度應大于(yu)2.0。取供試(shi)(shi)(shi)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)、對照(zhao)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)、二(er)甲(jia)基(ji)(ji)砜(feng)對照(zhao)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)各2µl，分別注入氣相(xiang)色(se)(se)譜儀，記(ji)錄色(se)(se)譜圖。供試(shi)(shi)(shi)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)如顯二(er)甲(jia)基(ji)(ji)砜(feng)峰(feng)，其(qi)與二(er)苯甲(jia)烷峰(feng)面(mian)積(ji)的比值，不得大于(yu)二(er)甲(jia)基(ji)(ji)砜(feng)對照(zhao)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)中二(er)甲(jia)基(ji)(ji)砜(feng)與二(er)苯甲(jia)烷峰(feng)面(mian)積(ji)的比值（0.1%）。供試(shi)(shi)(shi)品(pin)(pin)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)中所有(you)雜質(zhi)峰(feng)面(mian)積(ji)總和（除主峰(feng)及(ji)內(nei)標峰(feng)）與二(er)苯甲(jia)烷峰(feng)面(mian)積(ji)的比值不得大于(yu)對照(zhao)溶(rong)(rong)(rong)(rong)(rong)(rong)(rong)(rong)液(ye)(ye)(ye)(ye)(ye)中與二(er)苯甲(jia)烷峰(feng)面(mian)積(ji)的比值（0.1%）。

    不(bu)揮發殘留物 取本(ben)品100g，精(jing)密稱定(ding)，置105℃已干(gan)燥(zao)恒(heng)重(zhong)的蒸(zheng)發皿中，在通風櫥(chu)內置電(dian)熱板上緩(huan)緩(huan)蒸(zheng)發至(zhi)干(gan)（不(bu)發生沸騰(teng)），置105℃干(gan)燥(zao)3小時，稱重(zhong)。殘留物不(bu)得(de)過0.01%。

    【含量(liang)(liang)測定】按(an)以(yi)下公式計算(suan)本品的含量(liang)(liang)：

    （1-不揮發殘留(liu)物-有(you)關物質）

    含量= --------------------------------- ×

    （1-水分）

    【類別】藥用(yong)輔料，吸收(shou)促進劑、溶劑和防凍劑等（僅供外用(yong)）。

    【貯(zhu)藏】密閉，在陰(yin)涼、干燥處保存。